Regulation of Cardiolipin Remodeling in Human Lymphoblasts
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چکیده
منابع مشابه
Human Trifunctional Protein Alpha Links Cardiolipin Remodeling to Beta-Oxidation
Cardiolipin (CL) is a mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes involved in the generation of ATP. In order to facilitate its role CL must be remodeled with appropriate fatty acids. We previously identified a human monolysocardiolipin acyltransferase activity which remodels CL via acylation of monolysocardiolip...
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Cardiolipin (CL) synthase activity was characterized in mitochondrial extracts of the yeast Saccharomyces cerevisiae and was shown for the first time to utilize CDP-diacylglycerol as a substrate. CL synthase exhibited a pH optimum of 9.0. Maximal activity was obtained in the presence of 20 mM magnesium with a Triton X-100: phospholipid ratio of 1:1. The apparent Km values for phosphatidylglycer...
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1. E. K. McLean, Pharmac. Rev. 22, 429 (1970). 2. B. Meyrick, W. Gamble and L. Reid, Am. J. Physiol. 239, H692 (1980). 3. K. S. Hilliker, T. G. Bell and R. A. Roth, Am. J. Physiol. 242, H573 (1982). 4. J. M. Kay, P. M. Keane, K. L. Suyama and D. Gauthier, Thorax 37, 88 (1982). 5. L. Merkow and J. Kleinerman, Lab. Invest. 15, 547 (1966). 6. C. A. Wagenvoordt and N. Wagenvoordt, Circulation 42, 1...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.672.1